A Case of Behcet's Disease with Bilateral Pulmonary Artery Aneurysm

Behçet's disease is an autoinflammatory disease characterized by recurrent painful oral ulcers with small, medium and large diameter vessel involvement. Although the pathogenesis is not clearly understood, the hypersensitivity of T-cells to antigens is known to play an important role. The hyperactivation of T-cells leads to an increase in such proinflammatory cytokines as IFN-gamma and TNF-alpha, which are responsible for the symptoms of Behçet's disease. The primary clinical concerns are mucosa, skin and ocular lesions, while minor concerns are joint, neurological, gastrointestinal, vascular and pulmonary anomalies. Vascular involvement and pulmonary involvement, while rare, are the prominent clinical presentations. We present this case to literature as a rare example of bilateral pulmonary artery aneurysms.

Bilateral Pulmoner Arter Anevrizmasi ile Seyreden Behçet Olgusu

Behçet Hastalýðý, tekrarlayan aðrýlý oral ülserler ile karakterize ve küçük, orta, büyük çaplý damarlarý tutan otoinflamatuar bir hastalýktýr. Patogenezi net olarak bilinmemekle birlikte, T hücrelerin antijenlere karþý aþýrý duyarlýlýðý patogenezde önemli rol oynamaktadýr. T hücrelerinin aþýrý aktivasyonu, IFN-gama ve TNF-alfa gibi proinflamatuvar sitokinlerin miktarýnda artýþa yol açar. Bu sitokinler de Behçet Hastalýðýndaki semptomlardan sorumludur. Baþlýca klinik tutulumlar mukozal lezyonlarý, cilt lezyonlarý ve oküler lezyonlardýr. Minör tutulumlar ise eklem tutulumu, nörolojik tutulum, gastrointestinal tutulum, vasküler tutulum ve pulmoner tutulumdur. Vasküler tutulum ve pulmoner tutulum en nadir ancak en mortal seyreden klinik prezentasyonlardandýr. Bilateral pulmoner arter anevrizmasý literatürde nadir görüldüðünden olgumuz sunulmuþtur.