Posterior Mediastenin Nadir Bir T�m�r�: �yi Diferansiye Liposarkom

Kalbaran K�smet, G�zde; Okutan, Oguzhan; Mazmano�lu At�lman, Seda; Y�lmaz, Ismail

Cilt : 12 Say� : 1 Y�l : 2023

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Posterior Mediastenin Nadir Bir T�m�r�: �yi Diferansiye Liposarkom [Respir Case Rep]

Respir Case Rep. 2022; 11(3): 170-175 | DOI: 10.5505/respircase.2022.24650

Posterior Mediastenin Nadir Bir T�m�r�: �yi Diferansiye Liposarkom

G�zde Kalbaran K�smet¹, Oguzhan Okutan¹, Seda Mazmano�lu At�lman², Ismail Y�lmaz³
¹SB� Sultan 2. Abd�lhamid Han SUAM, G��s Hastal�klar� Servisi, �stanbul
²Haydarpa�a Numune E�itim ve Ara�t�rma Hastanesi, Patoloji Servisi, �stanbul
³SB� Sultan 2. Abd�lhamid Han SUAM, Patoloji Servisi, �stanbul

Liposarkom eri�kinlerde en s�k g�r�len yumu�ak doku sarkomlar�ndan biridir; genellikle alt ekstremitelerde ve retroperitonda ortaya ��kar. Miksoid, iyi diferansiye, farkl�la�mam�� (dediferansiye) ve pleomorfik olmak �zere �e�itli histolojik alt tipleri vard�r. Mediastenden kaynaklanan liposarkomlar son derece nadirdir. Bu t�m�rler genellikle yava� b�y�rler ve asemptomatik kal�rlar ancak b�y�k boyuta ula��p kom�u yap�lara bas� yapt��nda semptomatik olabilirler. Bilgisayarl� tomografi ve manyetik rezonans g�r�nt�leme tan� i�in faydal� veriler sa�lar. Kesin tan� i�in doku biyopsisi gereklidir ve tan�s� tipik patolojik �zelliklere dayan�r. Kemoradyoterapiye duyarl� olmad��ndan tam cerrahi rezeksiyon birinci basamak tedavi se�ene�idir. N�ks oran� y�ksek oldu�undan uzun s�reli takip yap�lmal�d�r. Bu yaz�da �ks�r�k �ikayeti ile ba�vuran primer mediastinal liposarkomlu 56 ya��nda kad�n olgu nadir g�r�lmesi sebebiyle sunuldu.

Anahtar Kelimeler: Atipik Lipomat�z T�m�r, CDK4, �yi Diferansiye Liposarkom, MDM2

A Rare Tumor of the Posterior Mediastinum: Well-Differentiated Liposarcoma

G�zde Kalbaran K�smet¹, Oguzhan Okutan¹, Seda Mazmano�lu At�lman², Ismail Y�lmaz³
¹Department of Chest Diseases, University of Health Sciences T�rki-ye, Hamidiye Faculty of Medicine, Sultan 2. Abd�lhamid Han Health Application and Research Center, �stanbul, T�rkiye
²Department of Pathology, Haydarpa�a Numune Training and Re-search Hospital, �stanbul, T�rkiye
³Department of Pathology, University of Health Sciences T�rkiye, Hamidiye Faculty of Medicine, Sultan II. Abd�lhamid Han Health Application and Research Center, �stanbul, T�rkiye

Liposarcoma is one of the most common forms of soft tissue sarcoma in adults, and usually occurs in the lower extremities and retroperitoneum. It has several histological subtypes, including myxoid, well-differentiated, dedifferentiated and pleomorphic. Liposarcomas originating from the mediastinum are extremely rare, and usually grow slowly and remain asymptomatic, but may become symptomatic when they become large enough to press on the adjacent structures. Computed tomography and magnetic resonance imaging provide useful data for diagnosis, while tissue biopsy based on typical pathological features is required for a definitive diagnosis. Complete surgical resection is the first-line treatment option as it is resistant to chemoradiotherapy. Due to the high risk of recurrence, long-term follow-up should be continued. We present here the rare case of a 56-year-old female patient with primary mediastinal liposarcoma who presented with a complaint of cough.

Keywords: Atypical Lipomatous Tumor, CDK4, Well-Differentiated Liposarcoma, MDM2

Olgunun G�r�nt� Kesitleri

G�zde Kalbaran K�smet, Oguzhan Okutan, Seda Mazmano�lu At�lman, Ismail Y�lmaz. A Rare Tumor of the Posterior Mediastinum: Well-Differentiated Liposarcoma. Respir Case Rep. 2022; 11(3): 170-175

Sorumlu Yazar: G�zde Kalbaran K�smet, T�rkiye
Makale Dili: �ngilizce

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