e-ISSN 2147-2475

Hzl Arama




Laparoscopic Endoscopic Surgical Science Dapsone Kullanmna Bal Gelien Methemoglobinemi Olgusu [Respir Case Rep]
Respir Case Rep. 2021; 10(2): 148-151 | DOI: 10.5505/respircase.2021.52385

Dapsone Kullanmna Bal Gelien Methemoglobinemi Olgusu

Emine Aksoy, zlem Yazcolu Moin
Salk Bilimleri niversitesi Sreyyapaa Gs Hastalklar ve Gs Cerrahisi Eitim ve Aratrma Hastanesi, stanbul

Methemoglobinemi, sklkla Dapsone ve Benzocain gibi ilalarn kullanmyla ortaya kan hayat tehdit eden bir durumdur. Dapson, B5 redktaz enzimini inhibe ederek eritrositlerde oksidasyonu azaltarak methemoglobinemiye neden olur. Bu makale de rtiker nedeniyle bir ay boyunca 100 mg / gn dapson kullanan methemoglobinemi olgusu sunuldu. Hasta bir haftadr devam eden eforla halsizlik, ate, terleme, peri-oral, periferik siyanoz ve cilt lezyonlar ile bavurdu. Pulse oksimetre ile llen oksijen satrasyonu % 88 idi. Arteryel kan gazndaki (AKG) methemoglobin (MetHb) seviyesi tan annda% 10,7 idi. Hastann takibinde, oksijen destei verildi ve Dapsone tedavisi kesildi. Hasta klinik takipte iyiydi ve 7. gnde AKG'da MetHb dzeyi normal snrlardayd (% 2,8) ve siyanoz saptanmad. Daha nce akcier veya kalp hastal olmayan siyanoz ile bavuran bir hastada methemoglobinemi aklda tutulmal ve ila yks de sorgulanmaldr.

Anahtar Kelimeler: Dapson, Methemoglobinemi, laca bal komplikasyonlar.

A Case with Methemoglobinemia due to Use of Dapsone

Emine Aksoy, zlem Yazcolu Moin
University of Health Sciences Sreyyapaa Chest Diseases and Thoracic Surgery Education and Research Hospital, stanbul, Turkey

Methemoglobinemia is a lethal condition that is most commonly seen with use of drugs such as dapsone and Benzocain. Methemoglobinemia associated with dapsone use is a result of decreased oxidation in erythrocytes due to the inhibition of the B5 reductase enzyme. We present here a case who developed methemoglobinemia while taking dapsone 100mg/day for a month due to urticaria. The male patent developed such symptoms as malaise, sub-febrile fever, sweating, peri-oral and peripheral cyanosis with exertion, and skin lesions for a week. Oxygen saturation with pulse oxymetry was 88%, and the methemoglobin (MetHb) level in the arterial blood gases (ABG) was 10.7% at time of diagnosis. The patient was monitored, oxygen was initiated and dapsone was discontinued. The patient recovered during follow-up and the MetHb level became normal (2.8%) in ABG on the 7th day, and the cyanosis disappeared. Patients presenting with cyanosis and with no known previous pulmonary or cardiac disease should be evaluated for Methemoglobinemia, and drug history of the patient should also be reviewed.

Keywords: Dapsone, Methemoglobinemia, Drugrelated complications.

Olgunun Grnt Kesitleri




Emine Aksoy, zlem Yazcolu Moin. A Case with Methemoglobinemia due to Use of Dapsone. Respir Case Rep. 2021; 10(2): 148-151

Sorumlu Yazar: Emine Aksoy, Trkiye
LookUs & Online Makale