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Laparoscopic Endoscopic Surgical Science Human Koryonik Gonadotropin Yanl Kullanm ile likili Pulmoner Tromboembolizm: Olgu Sunumu [Respir Case Rep]
Respir Case Rep. 2021; 10(2): 122-125 | DOI: 10.5505/respircase.2021.53824

Human Koryonik Gonadotropin Yanl Kullanm ile likili Pulmoner Tromboembolizm: Olgu Sunumu

Hlya Dirol1, Aye demi2, Tlay zdemir1
1Akdeniz niversitesi Tp Fakltesi, Gs Hastalklar Anabilim Dal, Antalya
2Artvin Devlet Hastanesi, Gs Hastalklar Klinii, Artvin

nsan koryonik gonadotropin (hCG) in obezite tedavisinde etkili olduuna dair ilk speklasyonlarn zerinden uzun yllar gemi olmasna ramen etkinlii kantlanamamtr. Ne yazk ki, pulmoner tromboembolizm ile komplike olan hCG ktye kullanm ile halen karlamaktayz. ncesinde bilinen bir hastal olmayan 54 yandaki kadn hasta plritik gs ars ile poliklinie bavurdu. Baka solunumsal semptomu yoktu. ki ay nce kilo vermek iin bir beslenme merkezine bavurmu ve 500 kcal / gn diyetle 125 IU / gn subkutan hCG enjeksiyonuna balamt. Hasta menopozda olmasna ramen enjeksiyonlardan sonra yzde kzarklk, memede ikinlik, minr vajinal kanama gibi ikayetleri gelimiti. Vital bulgular ve fizik muayenesi normaldi. D-dimer (610 ng / dL) deeri biraz yksek saptand. Ventilasyon / perfzyon sintigrafisinde mismatch subsegmental defektler grld. hCG enjeksiyonlar hemen durduruldu. Antikoaglan tedavi baland. Tedaviye 3 ay devam edildi ve imdiye kadar sorun yaanmad. Kilo kayb iin hCG yanl kullanm srasnda gelien bir iskemik inme ve bir pulmoner tromboembolizm olgusu bildirilmitir. Henz kesin olmasa da benzer olgu raporlar bu tr olaylarn bir ekilde HCG ile ilikili olduu phesini uyandrmaktadr. Mevcut olgularla bu noktaya daha fazla dikkat ekilmeli ve acilen hCG'nin diyet program olarak ktye kullanlmasyla ilgili yasal dzenleme hazrlanmaldr.

Anahtar Kelimeler: Pulmoner tromboembolizm, insan koryonik gonadotropin (hCG), obezite.

Pulmonary Thromboembolism Associated with Human Chorionic Gonadotropin Misuse: A Case Report

Hlya Dirol1, Aye demi2, Tlay zdemir1
1Department of Chest Diseases, Akdeniz University, Antalya, Turkey
2Department of Chest Diseases, Artvin State Hospital, Artvin, Turkey

Although many years have passed since the first speculation that Human chorionic gonadotropin (hCG) could be effective in obesity treatment, its efficacy in this regard has yet to be proven. Unfortunately, we still come encounter hCG misuse, complicated with pulmonary thromboembolism. A 54-year-old female patient with no prior medical history presented to the outpatient clinic with pleuritic chest pain, but no other respiratory symptoms. Two months earlier, she had applied to a nutrition center to lose weight and had been started on a 125 IU/day subcutaneous hCG injection and a 500 kcal/day diet. After the injections, she experienced such complaints as flushing, breast bulging and minor vaginal bleeding, despite having passed menopause. Her vital signs and all physical examinations were normal. D-dimer (610 ng/dL) was slightly elevated. Mismatched subsegmental defects were determined in a ventilation/perfusion scintigraphy. She ceased the hCG injections immediately, and anticoagulant treatment was started, continuing for 3 months, although recovery has been uneventful to date. Literature contains one case in which ischemic stroke and one case in which pulmonary thromboembolism developed during hCG misuse for weight loss. Although it has yet to be proven, similar case reports increase the suspicion that such events are somehow related with HCG. More attention should be paid to this point when encountering such cases, and urgent legal regulations regarding to the misuse of hCG as part of a diet program should be prepared.

Keywords: Pulmonary thromboembolism, human chorionic gonadotropin (hCG), obesity





Hlya Dirol, Aye demi, Tlay zdemir. Pulmonary Thromboembolism Associated with Human Chorionic Gonadotropin Misuse: A Case Report. Respir Case Rep. 2021; 10(2): 122-125

Sorumlu Yazar: Hlya Dirol, Trkiye
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